Director, Medicinal Chemistry - Cambridge, United States - Third Harmonic Bio
Description
The RoleThird Harmonic Bio is seeking a Director, Medicinal Chemistry to join us in our aim to become a leading small molecule company in the inflammation and immunology space.
The successful candidate will partner with the VP, Medicinal Chemistry, support and execute on the companys vision for Medicinal Chemistry and collaborate in supporting cross-functional project teams.
Seeking an individual who is driven to advancing the next wave of medicines to meaningfully improve the lives of patients.
ResponsibilitiesReporting to the VP, Medicinal Chemistry, implement and execute medicinal chemistry strategies to deliver high quality clinical candidatesSupport the scaling of the function including hiring medicinal chemists, setting goals, managing priorities and budgetsParticipate in Scientific Review Committee overseeing nonclinical projectsHelp direct chemistry team(s) at contract research site(s); possess in depth knowledge of medicinal chemistry and the drug discovery process, including lead optimization and DC nominationApply data visualization technologies and techniques to interrogate drug propertiesFacilitate cross-functional relationships by establishing strong collaborations across company including other nonclinical disciplines participating in project teamsApply different modalities of drug design (e.g., fragment screening, DNA encoded libraries, structure based) where appropriatePrepare high impact presentations for internal and external communicationSupport IP process, including status analysis, patent filing strategy and application.
Perform portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for discovery candidate nomination and compound advancementApply synthetic chemistry knowledge to drive compound design toward successful project progression and candidate drug delivery, assist the development of strategic, scientific, and technical strategies.
Minimum QualificationsPhD in synthetic organic or medicinal chemistry with 7-10 years post-doctoral experience in biotechnology/pharmaceutical industryMedicinal Chemistry expert with working understanding of biology, pharmacology, DMPK and toxicology and ability to integrate data from these disciplines to drive SARExperience working on cross-functional teams including an appreciation of the role of other disciplines in drug discoveryDemonstrated strong track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects to clinical candidate nominationWork in a hybrid environment with office presence 3 days a weekDesire to be part of a growing organizationGreat partnership skills and experience working in dynamic multidisciplinary environmentExtensive experience using external CROs for project executionTrack record of scientific excellence including patents, scientific publications and presentationsExcellent verbal and written communication skills and demonstrated ability to manage by influence and problem solve in a matrixed organizationDesired QualificationsExperience working on kinase inhibitor drug discoveryExperience leading cross functional project teamsThe approximate salary range for this role is: $194,000 - $220,000#J-18808-Ljbffr