- Lead and conduct in-depth research to investigate off-target effects associated with Mammoth nucleases across various cell types and organisms. Design and execute experiments to characterize off-target events of DSB and non-DSB technologies and identify novel strategies to minimize them effectively
- Develop, test, and optimize Mammoth's gene-editing tools to enhance on-target specificity and reduce off-target cleavage
- Analyze complex genomic datasets, employing bioinformatics tools and computational methods to identify and annotate off-target sites. Interpret data and draw meaningful conclusions to guide further research efforts
- Design and oversee validation studies to assess the efficacy and safety of newly developed CRISPR reagents and protocols in relevant biological systems. Validate protocols for regulatory submissions
- Collaboration: Collaborate closely with cross-functional teams, including molecular biologists, cell biologists, bioinformaticians, to integrate off-target findings into ongoing research projects and therapeutic programs
- Stay updated with the latest advancements in CRISPR and genome-editing technologies. Attend scientific conferences, present research findings, and publish in reputable peer-reviewed journals
- Ensure compliance with all relevant regulatory guidelines and ethical standards concerning genome editing and gene therapy
REQUIRED QUALIFICATIONS - Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related field with a strong focus on genome editing technologies
- 4 years minimum of industry experience for Sr. Scientist; 6 years minimum experience (can be combination of post-PhD academic and industry) for Principal Scientist
- Proven expertise in gene editing technology, with a specialization in off-target analysis and optimization
- 4 years experience in experimental design, execution, and data analysis related to genome editing and molecular biology techniques
- 3 years experience leading and mentoring scientists and collaborating cross functionally
PREFERRED QUALIFICATIONS - Experience in utilizing bioinformatics tools and software for the analysis of genomic data and CRISPR off-target prediction
- Strong track record of scientific publications and contributions to the field of genome editing
- Excellent problem-solving skills and a passion for innovation in gene-editing technologies
- Strong written and verbal communication skills, demonstrated by the ability to present complex scientific concepts to technical and non-technical audiences
BENEFITS - Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics benefits
- 401(k) with company matching
Base Salary Range: $ 155,000 - $188,000
The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company's ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth's deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law. -
Principal Scientist
1 week ago
Amgen Inc. South San Francisco, United StatesJOB ID: R LOCATION: US - California - South San Francisco WORK LOCATION TYPE: On Site DATE POSTED: Feb. 22, 2024 CATEGORY: Scientific SALARY RANGE: 138,904.00 USD - 165,489.00 USD · HOW MIGHT YOU DEFY IMAGINATION? · If you feel like you're part of something bigger, it's because y ...
-
Principal Scientist
1 week ago
BioSpace South San Francisco, United StatesJob Details · HOW MIGHT YOU DEFY IMAGINATION? · If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global col ...
-
Principal Scientist
1 week ago
Amgen South San Francisco, United States**HOW MIGHT YOU DEFY IMAGINATION?** · If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collabor ...
-
Principal Scientist, Bioanalytics
2 weeks ago
Astellas South San Francisco, United StatesPrincipal Scientist, Bioanalytics · Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of th ...
-
Principal Scientist, Bioanalytics
3 days ago
Astellas Pharma South San Francisco, United StatesPrincipal Scientist, Bioanalytics · Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of th ...
-
Principal/ Senior Principal Scientist
2 weeks ago
Genentech South San Francisco, United StatesThe Position · We advance science so that we all have more time with the people we love · The Translational Medicine department at Genentech provides translational research to inform clinical development in disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and ...
-
Principal Scientist, Bioanalytics
6 days ago
Astellas Pharma South San Francisco, United StatesPrincipal Scientist, Bioanalytics · Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of th ...
-
Senior/Principal Scientist
4 weeks ago
R&D Partners South San Francisco, United StatesBiotechnology company is hiring a Senior/Principal Scientist to support support clinical development of novel personalized therapeutics through established biomarker strategies. · Responsibilities · As a key member of the biomarker mass spectrometry laboratory, the ideal candida ...
-
Senior Scientist or Principal Scientist
2 weeks ago
Trova Talent South San Francisco, United StatesJob Description · Job DescriptionMy client is seeking a highly motivated, self-driven, collaborative and experienced individual with strong iPSC and cell engineering background. The successful candidate will be accountable for establishing control laboratory operation for iPSC se ...
-
Principal Scientist
4 weeks ago
Life Science People South San Francisco, United StatesJob Title: Senior Scientist/ Principal Scientist · Location: South San Francisco, CA · Company Overview: · Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing ...
-
Senior/Principal Scientist
2 weeks ago
Vilya, Inc. South San Francisco, United StatesJob Description · Job DescriptionVilya is a computational biotechnology company creating a novel class of medicines to precisely target disease biology. We believe computational approaches are an integral, if not foundational, component of drug discovery and development. Our plat ...
-
Senior/Principal Scientist
1 week ago
ICONMA, LLC South San Francisco, United States Full timeSenior/Principal Scientist · Location: South San Francisco, CA · Duration: 12 Months · Description: · The Translational Medicine department at Client informs clinical development of Client personalized therapeutics through establishment of biomarker strategies aimed to study bi ...
-
Principal Scientist
5 days ago
Amgen Foundation, Inc. South San Francisco, United States**Principal Scientist Biotransformation** · US , CA,South San Francisco · If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology ...
-
Principal Scientist
4 days ago
Genentech South San Francisco, United StatesYou will be:Working to identify new targets for drug development in AMD. Leading efforts relating to understanding disease pathogenesis in AMD. Success in these responsibilities requires a thorough understanding of disease and drug target biology, cr Biology, Scientist, Principal ...
-
Principal Scientist
1 week ago
Amgen South San Francisco, United States Full timeHOW MIGHT YOU DEFY IMAGINATION? · If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who ...
-
Principal Scientist
3 days ago
Life Science People San Francisco, United StatesJob Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA · Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet ...
-
Principal Scientist
1 day ago
Soleil Labs, LLC South San Francisco, United States**Principal Scientist** _Molecular Biology and Expression, Protein Sciences_**: · **May 2024**: · **Department**:Technology**: · ***: · **Work Location**: Corporate Headquarters (South San Francisco)**: · ***: · **Position Summary**: · ***: · **Responsibilities**: · - Lead and ma ...
-
Principal Scientist, Translational Medicine
2 weeks ago
Denali Therapeutics South San Francisco, United StatesThe Principal Scientist, Translational Medicine, is a position within Translational Medicine & Early Clinical Development (TM-ECD) that partners with experts in the Discovery and Development functions to build effective biomarker strategies that will enable execution of biomarker ...
-
Scientist III/Principal Scientist
3 days ago
Kanvas Biosciences San Francisco, United StatesSummary · Title: · Scientist III/Principal Scientist – Microbial Downstream Process DevelopmentDepartment: · Process Development and ManufacturingExempt/Non-exempt: · ExemptJob Location: · South San Francisco, CA · About Us · Kanvas Biosciences is a biotechnology company d ...
-
Scientist III/Principal Scientist
1 day ago
Kanvas Biosciences San Francisco, United StatesSummary · Title: · Scientist III/Principal Scientist Microbial Downstream Process DevelopmentDepartment: · Process Development and ManufacturingExempt/Non-exempt: · ExemptJob Location: · South San Francisco, CA · About Us · Kanvas Biosciences is a biotechnology company ded ...
Sr. Scientist I/II or Principal Scientist I - Brisbane, United States - Mammoth Biosciences
Description
OPPORTUNITYMammoth Biosciences is currently seeking a highly skilled and motivated scientist to join our expanding off-target team. You will be at the forefront of advancing our understanding and optimizing Mammoth's proprietary gene-editing technology, with a particular focus on measuring and minimizing off-target effects. Your expertise and leadership will be pivotal in developing innovative solutions to enhance the precision and safety of gene editing, revolutionizing the field of genome engineering.
KEY RESPONSIBILITIES