- Develops stable cell lines using techniques that deliver and integrate DNA/RNA into the host genome using lentivirus transduction, lipid-based transfection, and electroporation methods to support preclinical ADC research and development.
- Executes gene editing strategies to generate stable knockout cell lines using the CRISPR/Cas9 system and designs assays to monitor editing efficiency in support of target selection and preclinical research.
- Maintains and characterizes cancer cell lines and establishes banks for experimental purposes using aseptic cell culture techniques supporting research within the Targeted Therapeutics Group.
- Utilizes molecular biology techniques to conduct experiments involving DNA/RNA isolation and purification, expression construct design, molecular cloning and sub-cloning, RT-qPCR, PCR, sequencing, genotyping, and RNA profiling, contributing to preclinical and clinical research programs.
- Designs and executes cell-based and biochemical assays to validate engineered cell lines and targets through flow cytometry, reporter assays, ELISA, western blotting, and cytotoxicity assays to select lead preclinical candidates.
- Collects and analyzes data, interprets results, and presents results at internal research meetings contributing to go/no-go decisions on preclinical ADC programs.
- Engages in problem solving and the identification and development of new methodologies to improve efficiencies, expand capabilities, and advance projects from research into development.
- Executes a range of laboratory experiments efficiently and with high reproducibility to advance ADC research programs and overall corporate objectives.
- Bachelor's degree in a scientific discipline with minimum of two years of related laboratory experience
- Master's degree in a scientific discipline with related laboratory experience
- Bachelor's degree in a scientific discipline with minimum of five years of related laboratory experience
- Master's degree in a scientific discipline with minimum of two years of related laboratory experience
- Experience in molecular biology and mammalian cell expression technologies.
- Strong molecular biology background with a proficiency in DNA/RNA isolation and purification, cloning, sub-cloning, PCR, RT-qPCR, genotyping, expression construct design, transfection, CRISPR gene editing, and RNA profiling.
- Proficient in engineering stable overexpressing and CRISPR gene knockout cell lines and performing molecular and cell-based assays to validate the engineered cell lines.
- Hands-on experience with aseptic mammalian cell culture.
- Ability to execute experiments, develop assays, optimize protocols, and interpret experimental results.
- Capacity to manage multiple projects simultaneously and work effectively in a fast-paced, adaptive, collaborative environment.
- Ability to work independently, with minimal supervision.
- Problem solving skills, attention to detail, organized, ability to use good judgment.
- Ability to keep detailed and accurate notebooks and computer records and maintain/update data in computer-based applications/databases.
- Demonstrated strong written and oral communication skills, and ability to present results in a group setting
- None
- Experience with various software applications (Microsoft, GraphPad Prism, SnapGene, FloJo, BioIt, FreezerPro).
- Biochemistry and protein chemistry experience (flow cytometry, FACS, ELISA, western blotting, SDS-PAGE, etc.)
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Research Associate II - Rockville, United States - MacroGenics
Description
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development.
MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The Research Associate II / Associate Scientist I position will support preclinical development of MacroGenics antibody-drug conjugates (ADC) through cell line engineering and molecular biology support.
This position will independently develop and engineer cell lines, and conduct cell-based, molecular, and biochemical assays which contribute to the ADC research and development pipeline.
Responsibilities and Job DutiesResearch Associate II
Education & Other Credentials
Education & Other Credentials
MacroGenics is proud to be an equal opportunity employer.
Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law.
We are committed to working with and providing reasonable accommodation to individuals with disabilities.If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email or call and/or 711 for TTD/TTY service.
Equal Opportunity Employer/Veterans/DisabledWe do not accept non-solicited resumes or candidate submittals from search/recruiting agencies.
