- Develop and execute robust, scalable downstream processes for Dragonfly's novel multi-specific antibody and cytokine platforms ranging from purification, filtration, and analytical characterization
- Design and improve processes related to recovery, scalability and purity, prepare technical reports, SOPs, internal and external presentations
- Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
- Make informed decisions based on data analysis workup through excel or other statistical analysis software such as JMP
- Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
- Effectively maintain good communication and collaborate with cross-functional colleagues and external partners for successful execution/completion of projects
- Prepare reagents, buffers, and equipment as needed to support experiments
- Additional duties and responsibilities as required
- BS or MS degree in Chemical Engineering, Biochemical Engineering, Biochemistry or equivalent related fields with 3+ years relevant industrial experience required
- Strong hands-on experience in protein purification techniques such as filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems. Experience with different modes of chromatography is desirable
- Understanding of GxP activities such as reviewing GMP batch records, tech transfer reports, and campaign summary reports is desirable
- Experience with operating and programming high-throughput liquid handling platforms (e.g. TECAN, Hamilton, etc) is desirable
- Knowledge and skills in biochemical characterization of proteins including analytical and biophysical techniques
- The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills
Downstream Development Engineer - Waltham, United States - Dragonfly Therapeutics
Description
Downstream Development Engineer
Dragonfly Therapeutics seeks an Associate Engineer, Downstream who brings enthusiasm, intellectual curiosity, scientific rigor and a desire to help drive novel biologics programs. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic, and innovative individuals with a deep scientific interest in drug development, who thrive in a fast-paced, entrepreneurial environment.
Responsibilities:
Qualifications:
About Dragonfly
Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas.
Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.