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- Develop engraftment-competent human iHSCs
- Design and execute independent research on iHSCs, examining quality control aspects of cell production, translational function and safety with emphasis on oncogenic landscape analyses and safety issues related to long-term engraftment
- Derive and fully characterize different cell types from iHSCs, including designing assays to test their potentially improved function against aged HSCs
- Devise and test practical, innovative strategies to rejuvenate the aging human immune system, including testing interventions to combat thymic involution
Please apply if you have: - PhD or another advanced degree in Immunology or another biomedical science field
- Experience researching human hematopoietic stem cells and/or other aspects of immune regeneration
- Experience with iPSCs and iHSC-derived cell types
- Expert knowledge in experimental therapeutics and the therapeutic pipeline of primary HSCs and iHSCs, with an emphasis on practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation
- Extensive experience in bench molecular and small molecule biology, cell biology, immunology, hematology, hematopoiesis and bone marrow niche biology
Ideally, you'll also have: - Expertise in and working knowledge of age-related immune senescence and hematologic dysfunction
- General and working knowledge of aging biology, adult stem cells, regenerative and personalized medicine as well as gene therapy (AAV-mediated)
- Experience with in vitro and in vivo models of immune-senescence and regeneration
And you'll need:
- A friendly, easygoing personality
- The ability to work in the United States without sponsorship
Salary
Starting base pay range: $130,000/yr - $175,000/yrStarting additional compensation range: $7,500/yr - $17,500/yr
Starting position title and compensation are commensurate with experience.
- A friendly, easygoing personality
Scientist, Regenerative Medicine - Leonia, United States - InVitro Cell Research, LLC
Description
ICR is researching ways to regenerate the aged immune system. Immune senescence and decline underlie many of the most devastating age-related diseases. Our Regenerative Immunology program involves several approaches, including developing bone marrow-engraftable iPSC-derived hematopoietic stem cells (iHSCs) and implantable thymic organoids.
With us, you'll get to: