Postdoctoral positions in the integrative structural biology of cancer and immunity - Farmington, United States - University of Connecticut Health Center (UCHC)

Description

The position. The Page Laboratory at the University of Connecticut Health Center has an immediate opening for up to two postdoctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and phosphatase drug/inhibitor complexes. We use integrative structural and cell biology to tackle research problems in cancer, development and the immune system. All studies combine cryo-EM, NMR and/or X-ray crystallography with biochemical and cellular experiments, allowing postdocs to augment their training in cutting edge new techniques.

Recent high impact publications include (Nature: , Nature communications: , among others, ).

Applicants. Motivated applicants with strong backgrounds in biochemical and cell biology methods, and especially eukaryotic protein expression and/or CryoEM and protein crystallization, are encouraged to apply. PhD is required.

Laboratory alumni are highly successful, with either their own academic faculty positions at tier 1 research institutions (i.e., Vanderbilt University, Dartmouth University), are directors/chief scientists in big pharma and biotech startups, named prestigious public policy fellow, among others.

The laboratory. The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell biology groups at UConn Health. The Page laboratory is equipped with all necessary infrastructure to produce (E. coli, mammalian, insect), purify and analyze proteins and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam) as well as all needed equipment for cryo-EM sample preparation and data evaluation.

Facilities. UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR spectrometers). Cryo-EM instrument includes a TFS Vitrobot IV and a TFS Tundra/Falcon C) that allows for rapid screening of auto-grid/clipped samples of sample conditions. Access to Krios instruments for data collection is readily available.

UCHC. UCHC has a welcoming, collaborative and vibrant environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min).

Starting date, salary and project details are commensurate with experience, competitive and negotiable.

Please e-mail a Cover Letter and CV to Rebecca Page ).