Senior Scientist/Scientist - Maryland, United States - Hansoh Bio

Description

We are seeking a candidate who will be responsible for in vitro cell culture, basic molecular biology, immunoassays, protein expression, purification and characterization. The Maryland R&D site are focusing on the discovery of novel drug candidates for the treatment of cancer, renal, cardiovascular, and immune system diseases. Candidate is expected to maintain good experiment record and participate in lab management. The successful candidate will work directly with corporate partners, cross-functional teams and project teams to support our pre-clinical programs.

RESPONSIBILITIES

• and develop efficient molecular biology capabilities to generate DNA constructs for transient mammalian cell expression of antibodies and proteins to support therapeutic discovery and engineering efforts
• consistent and robust protein expression capabilities for transient 293 and CHO cells that encompass HTP small scale through gram level protein production
• antibody characterization utilizing ELISA, Octet or Biacore
• in vitro cell-based experiments using standard immunological, cellular and molecular biology techniques such as Western Blots, PCR/qPCR, ELISA, Luminex, flow cytometry, spectroscopy, and microscopy
• key scientific experiments together with project teams
• and ability to learn new skills to help contribute to our multi-disciplinary teams
• timely communication and presentations to project team and governance body
• with general lab management and upkeep including maintenance of biological samples, lab supplies, biological and chemical wastes, and calibration of instruments, in accordance with established guidelines
• maintenance of lab records and logs in accordance with the standard practices
• related research functions as deemed necessary to support day-to-day functioning of the lab

QUALIFICATIONS

1. degree in chemical biology, molecular biology, cell biology or equivalent scientific discipline from an accredited college or university with minimal 2 years of relevant experience
2. or M.S. degree in chemical biology, molecular biology, cell biology or equivalent scientific discipline from an accredited college or university with 10 years (with B.S.) or 5 years (with M.S.) of hands-on laboratory experience in an industrial or academic setting

• with variousin vitro and cell-based assay, mammalian cell culture, maintenance of cell lines, transfection, cell-based functional assays, flow cytometry, ELISA, Western Blots and PCR/qPCR
• with antibody characterization (LC-MS, HPSEC, Octet, Biacore) highly desired
• withÄKTA purification system or iQue3 preferred
• with GraphPad Prism software
• in cloning of antibody into expression vector, display technology, antibody humanization and affinity optimization preferred
• in computers with excellent record keeping, documentation and good organizational skills
• verbal and written communication and interpersonal skills, including ability to interpret and understand SOPs and laboratory procedures
• analytical with excellent trouble shooting skills
• forward thinking and motivated with ability to act independently