Developmental Systems Lead - San Francisco - Becoming

    Becoming
    Becoming San Francisco

    2 days ago

    Description

    About Becoming


    Becoming is building Developmental Intelligence: AI for predicting how organisms change over time.

    Most experimental systems fail when metabolic demands become too high. We are building systems that don't — enabling sustained, controllable biological processes over long time horizons so that development, adaptation, and failure can be observed, perturbed, and predicted.

    Physiology is central to this effort. Without stable, well-characterized physiological function, long-horizon prediction is impossible.

    The Role


    We are hiring a Developmental Systems Lead to own making externally sustained developmental systems run stably, repeatably, and predictably over days to weeks.

    This role is for someone who thinks in systems, not endpoints — someone who understands how transport, metabolism, signaling, mechanics, and homeostasis interact over time. You will lead the design and operation of systems that integrate perfusion, physiology, sensing, actuation, and closed-loop control to sustain and perturb development in ways that generate meaningful, causal data.

    This is a high-agency role. You will be expected to define measurements, interpret dynamics, and drive improvements in system-level function.

    What You'll Own

    • End-to-end responsibility for externally sustained developmental systems operating over days to weeks
    • Definition of what "success" means beyond "alive," including how stability, drift, and failure are measured over time
    • Identification, characterization, and mitigation of long-horizon failure modes (e.g., drift, inflammation, hemolysis, interface breakdown)
    • Design and refinement of closed-loop control strategies for complex biological systems
    • Integration of perfusion hardware, sensors, and control software into durable platforms
    • Decisions about when systems are sufficiently stable to perturb, compare, and learn from
    • Close collaboration with developmental biology, hardware, and ML / modeling teams
    • Building systems that improve with iteration, not systems that require constant manual expert intervention

    Who You Are


    You are someone who:

    • Operates with high agency — you identify what needs to be measured and why
    • Takes ownership of outcomes, not just data collection
    • Brings high energy to complex, dynamic biological systems
    • Acts with high integrity — you are honest about uncertainty, limits, and tradeoffs
    • Communicates directly and clearly, especially when systems are not behaving as expected
    • Is self-aware about your strengths and gaps, proactively fills them and open to feedback
    • Thinks like a systems integrator, not a siloed specialist

    Is comfortable working where physiology, engineering, and modeling intersect

    Required

    • Deep, hands‑on experience with long‑running biological or physiological systems (days+, not hours)
    • PhD or equivalent experience in physiology, engineering, or a related field
    • Experience with several of the following:
      • Perfusion systems involving blood or blood analogs
      • Hemodynamics, flow, pressure, and shear — and their biological consequences
      • Inflammation, coagulation, hemolysis, or endothelial failure in sustained systems
      • Closed‑loop control of noisy, drifting systems
      • Real‑time instrumentation and sensing in biological environments
      • Diagnosing failure modes that emerge gradually, not catastrophically
    • Ability to work fluently with developmental biologists and/or physiologists
    • At least 1 year of industry or applied systems experience

    Strong Signals

    • Background in perfusion, ECMO, organ support, or normothermic preservation
    • Physiology‑driven systems engineering experience
    • Experience with complex robotics or control systems operating in irreversible environments
    • History of systems that failed — and improved because of it

    Benefits

    • Competitive salary and meaningful equity
    • Full benefits
    • High‑trust, high‑ownership environment
    • Rapid growth in scope and responsibility

    #J-18808-Ljbffr

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