Project Lead Biologics, Amplify - Somerville

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Job description

Site:
Mass General Brigham Incorporated

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission.

As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care.

We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

This position offers a competitive base salary, dependent on experience, with a maximum of $275,000.

Job Summary

The Project Lead, Biologics is accountable for identifying, investing in, and leading technology projects and initiatives within the Amplify portfolio.

Amplify is the translational accelerator that funds and operates projects from Mass General Brigham investigators that have very high commercial potential.

The Project Lead will be a vital contributor to the success of Amplify in translating promising new idea to reality, and creating value with these new technologies.

The Project Lead, Biologics will act as the Chief Scientific Officer of their approved portfolio programs in a manner reminiscent of pre-seed/seeded new companies leveraging funding from Mass General Brigham.

The Project Lead, Biologics will participate and/or lead in the triage, diligence, planning, and investment approval process for select portfolio programs prior to operating the approved programs.

The Project Lead will also participate in commercialization activities including getting external feedback about prospective investments, and pitching to prospective investors and partners.

The Project Lead, Biologics candidate will combine their expertise in biologics therapeutic development and particular domains such as early stage proof of concept through preclinical development as well as project leadership to operationalize and de-risk early stage academic investigator technologies.

Candidates for this role will be highly motivated by the prospect of working on the forefront of life science innovation and advancing the healthcare mission of Mass General Brigham.

The ideal candidate will also have participated in fundraising and early stage company science operations.

Duties and Responsibilities

Leads assigned as well as invested projects in close collaboration with the Amplify leadership team, physicians and researchers at the hospitals, Innovation colleagues, and industry representatives.

The Project Lead Amplify will in effect perform as the principal of chief science/operational officer for their portfolio projects.

Applies knowledge of biologic therapeutic product development to effectively diligence, select, scope, plan/budget, pitch, and implement early innovative projects of their own, as well as assist in other project triage and diligences as part of the Amplify team.

Can readily assess commercial potential of assigned projects and assess the key risks to be mitigated.

Has a working understanding of intellectual property filing and prosecution, especially as it intersects with new company or partnership commercialization strategies.

Effectively conducts direct and regular interactions with hospital-based investigators and stakeholders, investors and industry collaborators, external advisors, contract vendors and consultants.

Runs the day-to-day science operations of multiple projects in collaboration with Mass General Brigham researchers, with oversight of external contract vendors and consultants engaged in activities that may include discovery to candidate nomination of biologic molecules, safety studies, product manufacturing, development of clinical and regulatory plans, and commercial analyses.

Effective in designing product/program plans to individual experiments, including analyzing and interpreting in vitro and in vivo datasets.

Capable of developing and managing program budgets and engaging with finance and operations colleagues to oversee spending, as well as inform commercialization plans.

Ensures that deliverables associated with each project is completed on time, within budget to meet or exceed targets set by Amplify.

Capable of producing high quality written materials for project operations, communications with stakeholders, and pitches for project approval to internal and external investment committees.

Thrives in working in close collaboration with colleagues working in diverse roles, including other Amplify Leads, MGB Ventures, MGB academic Innovators, BD & Licensing, and other MGB Translational Program Managers.

In addition to their Amplify responsibilities, the Project Lead will also serve as an experienced advisory resource to Venture and Licensing colleagues, as well as other Innovation colleagues engaged in translational development and initiatives for Mass General Brigham technologies.

Qualifications

Education and Experience

Advanced degree(s) in science/technology/engineering plus 5-10+ years of increasing responsibility in project management
Experience in industry-based drug product development environment of 10+ years is required
Prior experience in diligencing technologies either internally at a company or as a consultant to companies or investors
Experience in successfully fundraising and operating in a startup environment is a plus
Expertise with product development of biologic therapeutics including antibodies, ADCs, enzymes, recombinant fusion proteins, vaccines

Familiarity with technologies and platforms used to develop biologic therapeutics including immunization, library screening, in silico and structural design, as well as production of research grade to GMP proteins, plasmids, and cell lines.

Deep and demonstrated experience with immunology and/or cell biology
Strong ability to connect fundamental target biology to drug mechanisms
Extensive capability across a wide range of technologies in assay development
Proficiency in Microsoft Office applications as well as project management tools
Strong ability to manage competing complex deliverables and deadlines
Demonstrates exceptional verbal, writing, presentation skills
Established network of drug development contacts as well as investors is preferred
Enthusiasm for working with exceptional and innovative researchers and technologies
Specific expertise with biologic drug development of monoclonal antibodies, recombinant enzymes and other proteins, vaccines, is essential

Experience in overseeing IND-enabling activities including non-clinical pharmacology and CMC, and advancing programs to the IND stage or beyond is beneficial.

Additional Job Details (if Applicable)

Remote Type

Hybrid

Work Location

399 Revolution Drive

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

Pay Range

$147, $213,959.20/Annual

Grade

9

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization.

Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors.

The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package.

In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

EEO Statement

0100 Mass General Brigham Incorporated is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law.

We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level.

The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success.

These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.