- Lead a team of Scientists and Research Associates to develop epigenetic reprogramming therapies while remaining involved in day-to-day execution
- Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
- Contribute to NewLimit's product development decisions, company-wide goals, and technology platform
- Serve as a company-wide expert on metabolic diseases and liver biology
- Develop assays to measure hepatocyte function both ex vivo and in vivo
- Evaluate epigenetic reprogramming payloads using ex vivo and in vivo functional assays to select therapeutic candidates
- Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
- Experience leading a cross-functional team and managing direct reports
- Experience with therapeutic development, as demonstrated through contributions to a pre-clinical or clinical stage program
- Experience designing and executing experiments in animal models of liver dysfunction
- Deep knowledge of metabolic disease, liver biology, and relevant therapeutic modalities
- Experience with in vivo nucleic acid delivery technologies (e.g. viral vectors, endosomes, lipid nanoparticles)
- Experience with bulk and single cell functional genomics methods
- Experience with iterative product development cycles (e.g. design-build-test-learn)
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
- Meals and snacks on-site
-
Advisor - Dmpk
4 days ago
Lilly San Francisco, United StatesAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve th ...
-
Vice President, Therapeutic Discovery
5 days ago
Insitro South San Francisco, United StatesThe Opportunity · insitro is pioneering a new approach to drug discovery and development, enabled by the use of advanced machine learning to interrogate large amounts of cellular, molecular and clinical data to increase the probability of clinical success. The insitro platforms a ...
-
Contract - Research Associate (DMPK)
5 days ago
Cytokinetics South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
-
Senior Scientist, Disease Biology
5 days ago
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native Complex Platform recapitulates GPCR ...
-
Senior Scientist, Disease Biology
5 days ago
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native ComplexTM Platform recapitulates GP ...
-
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native Complex Platform recapitulates GPCR ...
-
Septerna South San Francisco, United StatesThe Company · Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients. The company's Native ComplexTM Platform recapitulates GP ...
-
Associate Director, Pharmacology
5 days ago
Cytokinetics, Incorporated South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
-
Director, Advocacy Engagement
5 days ago
Structure Therapeutics Inc South San Francisco, United StatesStructure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company's platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data i ...
-
Postdoctoral Fellow
6 days ago
Cytokinetics South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
-
Director, Clinical Operations
5 days ago
Structure Therapeutics Inc South San Francisco, United StatesStructure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company's platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data i ...
-
Associate Director, Clinical Science
2 weeks ago
Maze Therapeutics South San Francisco, United States Full timeThe Position: · At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for an Associate Director, Clinical Science to join o ...
-
Associate Director, Clinical Science
5 days ago
BioSpace South San Francisco, United StatesJob Details · The Position: · At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for an Associate Director, Clinical Sci ...
-
senior director
2 weeks ago
Insitro South San Francisco, CA, United StatesThe Opportunity · The heart of insitro's strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and small molecule discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an inc ...
-
Research Lab Manager
1 week ago
Cytokinetics South San Francisco, United StatesCytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle p ...
-
Senior Director, Clinical Pharmacology
5 days ago
BioSpace South San Francisco, United StatesJob Details · The Position: · At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmac ...
-
Senior Director, Clinical Pharmacology
2 weeks ago
Maze Therapeutics South San Francisco, United StatesThe Position: · At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join ...
-
Senior Director, Clinical Pharmacology
4 weeks ago
Maze Therapeutics South San Francisco, United States Full timeThe Position: · At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Director, Clinical Pharmacology to join ...
-
Clinical Scientist
2 weeks ago
Structure Therapeutics Inc South San Francisco, United StatesStructure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company's platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data i ...
-
Clinical Scientist
5 days ago
Structure Therapeutics Inc South San Francisco, United StatesStructure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company's platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data i ...
Group Leader, Metabolism - South San Francisco, United States - NewLimit
Description
Company infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking a liver biologist with leadership experience to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease.
In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As the leader of the Metabolism team, you will:
NewLimit offers generous benefits to ensure our team can focus on our mission: