Brad E. Hoffman, PhD

Senior researcher with over 20 years of experience in immune tolerance and central nervous system autoimmunity. Expertise in adeno-associated virus (AAV)-mediated induction of antigen-specific regulatory T cells for therapeutic applications in Multiple Sclerosis and Neuromyelitis Optica. Skilled in T and B cell biology, molecular immunology, and translational research strategies for autoimmune disorders. Proven track record in leading experimental design, data analysis, and collaborative projects across academic and clinical settings.

• Over 20 years of research in immunology and neuroimmunology with a focus on autoimmune diseases of the central nervous system.

• Extensive expertise in antigen-specific immune tolerance strategies, including AAV-mediated induction of regulatory T cells.

• Developed and optimized preclinical models of Multiple Sclerosis and Neuromyelitis Optica incorporating T and B cell responses.

• Led multidisciplinary projects on molecular pathways of neuroinflammation and immune dysregulation.

• Strong background in translational research bridging basic immunology and therapeutic development.

• Published numerous peer-reviewed articles and secured competitive research funding.

• Experienced in mentoring graduate students and collaborating across academic and clinical teams.

Education

• Bachelor of Science in Chemistry, minor in Biology, University of Central Florida, Orlando, FL, 1994

• Ph.D. in Microbiology and Immunology, Temple University, School of Medicine, Philadelphia, PA, 2006

• Postdoctoral Research Fellow in Cell and Molecular Therapy, University of Florida, College of Medicine, Gainesville, FL, 2006