- Establish rapid, safe, cost-effective, and efficient intracellular delivery methods for genes and genome-editing machinery. The goal of this NIH-funded project is to establish new manufacturing platforms for gene and stem cell-based therapies directed at pediatric cancers, hematologic disorders, primary immunodeficiencies, and other genetic diseases.
- Design and apply nanocarrier systems to enable cystic fibrosis gene therapies.
- Develop microfluidic liquid biopsy technologies for monitoring treatment response to pediatric sarcomas and other childhood malignancies
- Apply rapid prototyping approaches to fabricate three-dimensionally printed tools for organoid development & toxicity screening of electronic cigarette/vaping products
- PhD, MD/PhD, or equivalent in Bioengineering, Materials Science, Chemistry, Mechanical Engineering, Physics, Electrical Engineering, Molecular Biology or related life science fields of study
- Background in nanoparticle synthesis & characterization and mRNA therapeutics
- Solid understanding and experience in micro/nanofabrication techniques, microfluidic devices, three-dimensional printing, device design and characterization
- Experience in cell culture, cell biology & molecular biology, immunofluorescence/flow cytometry, next generation sequencing techniques, gene editing methods, and biochemical techniques desired
- Ability to multitask and quickly adapt to new research challenges
- Excellent communication skills and ability to work in a diverse, interdisciplinary research environment and to interact with computational and experimental scientists
- Ability to function independently in the laboratory and lead project teams
- Desire to engage and mentor graduate, medical, and undergraduate students across different academic disciplines
- Experience with micro/nanofabrication techniques, including photolithography and three-dimensional printing for rapid prototyping and application of microfluidic systems
- Experience in the design of computer models/simulations for prototyping of project-specific devices
- Experience in nanoparticle synthesis and characterization (e.g., lipid nanoparticles, polymeric, plasmonic nanomaterials)
- Experience with cell culture, transfection, immunofluorescence/flow cytometry, and biochemical and molecular biology techniques
- Comfortable working with human primary cell types including hematopoietic stem cells, immune cells, or pluripotent stem cells.
- Experience in the development and characterization of gene editing reagents, PCR, cloning, and/or Next-Generation sequencing desired
- Working knowledge of laboratory notebook management and data management
- Knowledge of aseptic and laboratory technique
- Meticulous organizational and data analysis skills
- Coordination of project activities and collaborative efforts. The candidate will report directly to the PI.
- Oversee development of technology platforms for cellular therapy manufacturing and characterization of cell products resulting from this work
- Ability to multitask and contribute to multiple projects efficiently and effectively
- Supervision, mentorship, and teaching of undergraduate, graduate, and medical students, new postdoctoral trainees, and staff research associates in the lab
- Required to communicate well with other scientists, regulatory personnel, biotech companies, sponsored research organizations, and other scientific personnel worldwide.
- Preparation of manuscripts for publication of results of independent and collaborative laboratory research. The candidate will also provide support in publishing the results of various projects.
- Participate in laboratory meetings, educational sessions, general and specific safety training and other training sessions
- Assist with preparation of grant proposals and progress reports, as needed
- Performs other duties and laboratory responsibilities as requested.
- Ph.
- Curriculum Vitae - Your most recently updated C.V.
- Cover Letter
- Statement of Research
- Statement on Contributions to Equity, Diversity, and Inclusion - An EDI Statement describes a faculty candidate's past, present, and future (planned) contributions to equity, diversity, and inclusion. To learn more about how UCLA thinks about contributions to equity, diversity, and inclusion, please review our EDI Statement FAQ document.
- 3 letters of reference required
-
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Pediatric Hematology Oncology - Los Angeles, United States - UCLA
Description
Position overviewSalary range:
$64,480 - $77,327
Application Window
Open date:
April 30, 2024
Next review date:
Thursday, May 30, 2024 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.
Final date:
Tuesday, Apr 29, 2025 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The Jonas Lab in the Department of Pediatrics, David Geffen School of Medicine & California NanoSystems Institute at UCLA is seeking motivated postdoctoral researchers interested in pursuing interdisciplinary research at the interface of nanoscience and regenerative medicine.
We have a multidisciplinary research team interested in developing new nanotechnology-enabled methods to support the childhood cancer and regenerative medicine research communities in accelerating the discovery and implementation of gene and cellular therapeutic approaches and precision-medicine-based diagnostic strategies.
With support from the NIH's High-Risk High-Reward Program, our group leverages advances in microfluidics, nanofabrication, and gene editing approaches to explore the ultimate limits of miniaturization.
These capabilities empower our efforts to create tools that enable stem cell biologists to probe and to interact with stem cells more precisely and empower clinical scientists to apply this knowledge to design and implement new therapies more rapidly and broadly.
We have multiple postdoctoral positions available immediately to:
Qualifications:
Skills:
Duties and Responsibilities:
Cultural North Star
The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what's right, making things better, and being kind.
Anti-Racism Roadmap
The David Geffen School of Medicine Anti-racism roadmap is our co-created path to ensuring racial justice, equity, diversity and inclusion.
Qualifications
Basic qualifications (required at time of application)
Application Requirements
Document requirements
Apply link:
Help contact:
About UCLA
As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time.
The University of California is an Equal Opportunity/Affirmative Action Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
For the complete University of California nondiscrimination and affirmative action policy, see:UC Nondiscrimination & Affirmative Action Policy.
Job location
Los Angeles, CA
